Accomplished scholar with expertise in research, academic writing, and teaching. Demonstrated ability in critical thinking and problem-solving, supported by a strong record of scholarly publications and presentations. Committed to fostering engaging discussions and promoting intellectual growth through qualitative research and data analysis. Recognized for high productivity and efficient task execution in academic settings.
1. Chun Chen, Jianming Liao, Yiyuan Xia, Xia Liu, Rheinallt M.Jones, John P.Haran, Beth A.McCormick, Timothy R. Sampson, Ashfaqul Alam and Keqiang Ye,2021. Gut Microbiota Regulate Alzheimer’s Disease Pathologies and Cognitive Disorder via PUFA-Associated Neuroinflammation. Gut. 2022 Nov;71(11):2233-2252.
2. Chun Chen, Yunzhe Zhou, Hualong Wang, Ashfaqul Alam, Seong Su Kang, Eun Hee Ahn, Xia Liu, Jianping Jia, and Keqiang Ye, 2021.Gut inflammation triggers C/EBPβ/δ-secretase-dependent gut-to-brain propagation of Aβ and Tau fibrils in Alzheimer’s disease. EMBO J, 2021 Sep 1;40(17):e106320
3. Chun Chen, Eun Hee Ahn, Xia Liu, Zhihao Wang, Shilin Luo, Jianming Liao and Keqiang Ye, 2021. Optimized TrkB Agonist Ameliorates Alzheimer’s Disease Pathologies and Improves Cognitive Functions via Inhibiting Delta-Secretase. ACS Chem Neurosci,2021, Jul 7:12(13):2448-2461
4. Jianming Liao, Chun Chen*, Eun Hee Ahn, Xia Liu, Hua Li, Laura E Edgington-Mitchell, Zhonghua Lu, Shuping Ming, and Keqiang Ye, 2021. Targeting both BDNF/TrkB pathway and delta-secretase for treating Alzheimer’s disease. Neuropharmacology.2021, Jul 31;197:108737. (equally contribution as co-first author)
5. Zhourui Wu, Chun Chen, Seong Su Kang, Xia Liu, Xiaohuan Gu, Ping Yu, Christopher Dirk Keene, Liming Cheng and Keqiang Ye,2021. Neurotrophic signaling deficiency exacerbates environmental risks for Alzheimer’s disease pathogenesis. PNAS, 2021 Jun 22;118(25):e2100986118.0
6. Kecheng Lei, Seong Su Kang, Eun Hee Ahn, Chun Chen, Jianming Liao, Xia Liu, Hua Li, Laura E.Edgington-Mitchell, Lingjing Jin and Keqiang Ye, 2021. C/EBPβ/AEP signaling regulates the oxidative stress in Malignant Cancer, stimulating Metastasis. Mol Cancer Ther.2021 Sep;20(9):1640-1652.
7. Chun Chen, Eun Hee Ahn, Seong Su Kang, Xia Liu, Ashfaqul Alam, and Keqiang Ye. Gut dysbiosis contributes to amyloid pathology, associated with C/EBPβ/AEP signaling activation in Alzheimer’s disease mouse model. Sci Adv. 2020 Jul 29;6(31):eaba0466.
8. Kaj Blennow, Chun Chen, Claudia Cicognola, Kristin R Wildsmith, Paul T Manser, Sandra Sanabria, Zhentao Zhang, Boer Xie, Junming Peng, Oskar Hansson, Hlin Kvartsberg, Erik Portelius, Henrik Zetterberg, Tammaryn Lshley, Gunnar Brinkmalm, Geoffrey A.Kerchner, Robby M Weimer, Keqiang Ye, and Kina Hӧglund. 2020. Cerebrospinal fluid tau fragment correlates with tau PET: a candidate biomarker for tangle pathology. 2020 Feb 1;143(2):650-660.
9. Chun Chen, Zhihao Wang, Zhentao Zhang, Xia Liu, Seong Su Kang, Ying Zhang, and Keqiang Ye, 2018. The prodrug of 7,8-Dihyroxyflavone development and therapeutic efficacy for treating Alzheimer’s disease. PNAS, 2018,115(3): 578-583.
10. Yufeng Chen, Zhenlei Zhao, Guobin Xia, Fan Xue, Chun Chen and Ying Zhang.2020. Fabrication and characterization of zein/lactoferrin composite nanoparticles for encapsulating 7,8-dihydroxyflavone: Enhancement of stability, water solubility and bioaccessibility. Int J Biol Macromol.2020 Mar 1;146:179-192.
11. Yufeng Chen, Fan Xue, Guobin Xia, Zhenlei Zhao, Chun Chen, Yunhong Li, and Ying Zhang, 2019. Transepithelial transport mechanism of 7,8-dihydroxyflavone, a small molecular TrkB receptor agonist, in human intestinal Caco-2 cells. Food & Function. 2019 Aug 1;10(8):5215-5227.
12. Yufeng Chen, Lu Jin, Yunhong Li, Guobin Xia, Chun Chen and Ying Zhang. 2018. Bamboo-shaving polysaccharide protects against high-diet induced obesity and modulates the gut microbiota of mice. Journal of Functional Foods.2018 Oct. 49:20-31.
13. Yunhong Li, Jianxin Han, Yufeng Chen, Chun Chen, Bingquan Chu and Ying Zhang.2018. p-Coumaric acid as a prophylactic measure against normobaric hypoxia induced pulmonary edema in mice. Life Sci.2018 Oct. 15;215-223.
14. Bingquan Chu, Chun Chen, Jiaojie Li, Xiaojian Chen, Yunhong Li, Weimin Tang, Lu Jin, and Ying Zhang. 2017. Effects of Tibetan Turnip (Brassica rapa L.) on Promoting Hypoxia-Tolerance in Healthy Human. Journal of Ethnopharmacology. 2017 Jan.195:246-254.
15. Zejin Wang and Chun Chen, 2014. Research on Cold Storage and Transport Technologies for Guanxi Pomelo, Proceeding of the 3rdIIR International Conference on Sustainability and Cold Chain, London, UK.
16. Chun Chen, Zejin Wang, and Aiqing Luo, 2013.Effect of storage temperature and period on the amount of probiotics in yogurt products. Proceedings of Annual academic conference on Refrigeration, Wuhan, China.
17. Chun Chen, Zejin Wang, and Ming Mu, 2013. Inhibit Effect of Ultra-low temperature on growth of microorganism. Proceedings of the 5thConference on Innovation and Development of Refrigeration Industry in China, Xiamen, China.
18. Zejin Wang and Chun Chen, 2011. Research and Application in New Type of Cooling Device in High Humidity Cold Store, Proceedings of the 23rd International Congress of Refrigeration, Prague, Czech Republic.
19. Chun Chen, 2009. Effectiveness of treatment with Artemisia argyi powder in banana storage. Proceedings of Conference on Progress of Food Refrigeration Technology and Refrigerator Energy, Fuzhou, China.
20. Chun Chen, Zejin Wang, 2008. Advanced research into the inhibition activities of Artemisia argyi plant extract and prospects for its application. Proceedings of Conference on Progress of Food Refrigeration Technology and Refrigerator Energy, Fuzhou, China.